Semorelin and HCG

What is Sermorelin Acetate?

Sermorelin (GHRH) is a bio-identical hormone that has recently been genetically engineered to stimulate the secretion of Growth Hormone Releasing Hormone (GHRH) from the hypothalamus, a gland adjacent to the pituitary gland.

GHRH is a peptide that contains the first 29 amino acids of our own GH. These 29 amino acids are the active amino acids of GHRH. It is GHRH that stimulates the pituitary glands to release GH. As we get older, the hormones produced by the anterior pituitary are depleted. It has now been shown that GHRH can restore the GH-RNA to a youthful level causing elevation of levels of IGF-1.

How does Sermorelin come?

Sermorelin is presented in a multi-dosed, injectable vial.  Each vial contains a powder disc which contains 15mg (15,000 micrograms) of lyophilized Sermorelin Acetate. The vial is vacuum sealed by the pharmacy for your protection and for the preservation of the hormone peptide.  Each Sermorelin vial also comes with a bottle of Bacteriostatic Water as a diluent.  The Bacteriostatic Water is mixed with the Sermorelin to provide solution for injection.  Administration and storage instructions will be provided with your prescription. Sermorelin is presented in a multi-dosed, injectable vial.  Each vial contains a powder disc which contains 15mg (15,000 micrograms) of lyophilized Sermorelin Acetate. The vial is vacuum sealed by the pharmacy for your protection and for the preservation of the hormone peptide.  Each Sermorelin vial also comes with a bottle of Bacteriostatic Water as a diluent.  The Bacteriostatic Water is mixed with the Sermorelin to provide solution for injection.  Administration and storage instructions will be provided with your prescription.

How do I take Sermorelin?

Sermorelin is injected into the body fat, subcutaneously, using a very small needle similar to what a diabetic uses to inject insulin.  Injections are initially prescribed for every day and are decreased in frequency over time.

When do I take Sermorelin?

The best time to take Sermorelin is prior to bedtime.  Growth Hormone is primarily released during sleep and most beneficial to the body’s recovery and repair during this time.  Sermorelin has a promoting effect on sleep and can therefore make you tired if taken during the day.

How do you measure the effectiveness of Sermorelin?

Due to the pulsatile nature of both endogenous HGH and IGF-1, a single blood draw is not sufficient for accurate measurement.   Most physicians who prescribe Sermorelin and similar peptides measure effectiveness in patients through symptomology (the study of your symptoms-see benefits); physical appearance and measurements; and more frequent blood analysis.

How will I know its working?

After 4 years of observing patients taking Sermorelin, studies have noticed that patients usually report improved sleep within the first few weeks of therapy.  Of course, this is only noticed in patients who have trouble sleeping in the first place, however most patients at least notice an increase in sleep quality.  This is usually concurrent with increased energy levels and improved mood.  After 3-6 months of therapy patients start reporting noticeable or significant body changes, such as increase in muscle tone and a leaner physique. Over time patients will also notice a significant improvement in skin tone and health.

How long does it take to work?

Just like most peptide hormones, Sermorelin usually has a “loading” period of 3-6 months before full effects are noticed.  Once injected, both Sermorelin and rHGH are eliminated from then body very quickly and therefore need to be injected frequently.  Its actions are dependent on a chain reaction of biological processes which result in elevated and sustained HGH and growth factors.  It takes some time for levels to become optimal and initiate the benefits we are seeking to achieve.

Do I need to take Sermorelin forever to keep seeing results?

Actually, no.  Sermorelin has an ongoing effect in which optimal HGH levels can be sustained long after the last injection.  Just like synthetic HGH, Sermorelin initially must be injected every day.  Unlike synthetic HGH, once optimal levels are sustained with Sermorelin injection frequencies can be decreased or stopped altogether.  Once results are achieved, patients are then switched to a maintenance protocol eliminating the need for ongoing daily injections and reducing the total cost of therapy!


HCG Overview

Human chorionic gonadotropin (hCG) is sometimes called “the pregnancy hormone” because of its important role in maintaining pregnancy. Pregnancy tests check hCG levels in the urine or blood to determine if the test in positive or negative.

HCG injection is also approved by the U.S. Food and Drug Administration (FDA) to treat specific medical conditions in both women and men.

In women, hCG injections are FDA-approved to help treat infertility and weight loss.

In men, hCG injections are FDA-approved for a type of hypogonadism in which the body doesn’t adequately stimulate the gonads to produce the sex hormone testosterone and for weight loss.

What is it used for in men?

In men, doctors prescribe hCG to combat the symptoms of hypogonadism, such as low testosterone and infertility. It can help the body increase production of testosterone and increase sperm production, which can reduce infertility.

Injections of hCG are also sometimes used as an alternative to testosterone products in men with testosterone deficiency. Testosterone deficiency is defined as testosterone blood levels less than 300 nanograms per deciliter along with symptoms of low testosterone. These include:

  • fatigue

  • stress

  • low sex drive

  • depressed mood

According to the American Urological Association, hCG is appropriate for those men with testosterone deficiency who also desire to maintain fertility.

Testosterone products boost levels of the hormone in the body but can have the side effects of shrinking the gonads, altering sexual function, and causing infertility. HCG can help increase testosterone levels, increase fertility, and increase gonad size.

Some doctors think that using testosterone along with hCG might improve symptoms of testosterone deficiency while preventing some of the testosterone side effects.

There is also speculation that hCG might help improve sexual function in men who don’t have improvement while on testosterone.

Bodybuilders who take anabolic steroids such as testosterone also sometimes use hCG to prevent or reverse some of the side effects cause by steroids, such as gonad shrinkage and infertility.

How does it work to increase testosterone?

In men, hCG acts like luteinizing hormone (LH). LH stimulates Leydig cells in the testicles, which results in the production of testosterone. LH also stimulates production of sperm within structures in the testicles called seminiferous tubules.

As hCG stimulates the testicles to produce testosterone and sperm, the testicles grow in size over time.

What does the research say?

Very little clinical research has evaluated hCG in men with low testosterone levels. In a small study of men with hypogonadism, hCG increased testosterone levels compared to a placebo control. There was no effect of hCG on sexual function.

In one study, men taking testosterone along with hCG were able to maintain adequate sperm production. In another study, men taking testosterone along with hCG were able to maintain testosterone production in the testicles.

In rare cases, people taking hCG have developed blood clots. Although also rare, allergic reactions can occur, including mild skin rashes and severe anaphylactic reactions.

Can it be used for weight loss?

HCG is often used for weight loss. Several products are available that are marketed as over-the-counter homeopathic hCG products for weight loss.

However, the FDA has warned that there are no FDA-approved hCG products for this purpose. Over-the-counter products claiming to contain hCG aren’t legally authorized.

Safety information

When used appropriately with the guidance of your doctor, hCG is safe. It shouldn’t be used by men with prostate cancer, certain brain cancers, or uncontrolled thyroid disease. Talk with your doctor about your other medical conditions before using hCG.

The takeaway

HCG is an FDA-approved medication for treating specific conditions in both women and men. In men, it seems to have an important role as an alternative to testosterone for boosting testosterone levels and maintaining fertility.

Some doctors are prescribing it in conjunction with testosterone products for testosterone deficiency to help maintain fertility and sexual function.

Some people are also using hCG for weight loss, often as a component of the hCG diet