PRP - Platelet Lysate

You may have heard of platelet rich plasma or PRP, which is concentrating blood platelets and injecting them to prompt healing. Platelet Lysate (PL) is it’s more advanced cousin. We first began using PL in orthopedic injuries in 2005. It’s just now starting to catch on via other clinics trying to replicate what we do.

what is platelet lysate and why is it important?

Platelets live in your blood. They are little fragments of cells that are stocked with growth factors and initiate clotting. When you get a cut, it bleeds and the platelets are nanomachines that help to stop the bleeding via a blood clot. The clot is more than just glue to stop the flow of blood out of damaged vessels, it’s also nature’s advanced biologic scaffold to initiate and support healing. Within that healing matrix are billions of platelets that excrete growth factors. These specialized chemicals “speak” to other cells, telling them what to do and energizing the construction effort. We like to tell patients that these growth factors inside platelets act like espresso shots for the cells that are repairing damaged tissue.

PRP is simply concentrating the platelets in the blood. PRP works by concentrated platelets slowly releasing growth factors over approximately a week. Sort of like a timed release version of a pill. What if you want an immediate release version with many more growth factors available all at once? You use a platelet lysate (PL). In our experience while PRP can cause inflammation, PL is very anti-inflammatory and hence can be used more easily around nerves. The 1st generation PRPs were red and the newer PRPs are amber, having eliminated the pro-inflammatory red and white blood cells. Our 2nd generation PRP can be concentrated to ultra-high levels, so we call it SCP (Super Concentrated Platelets). At this time we are the only clinic in Brevard County using this 2nd generation PRP.

What does platelet lysate help with?

Ultimately, PL help multiple injuries and diseases in such areas as shoulder, neck, spine, knees, ankles and feet, hips, wrists and hands, elbows, hair restoration, and skin impurities. Example: Epidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficiency is limited. In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet rich plasma (PRP) instead of epidural injections for the treatment of radicular pain as an alternative to corticosteroids.


The upshot? While the rest of the world is struggling to figure out how to make a first generation platelet lysate, we’ve been using our third generation procedure for over a year and are now working on the fourth generation procedure. Why spend all of the money on continually improving what we do at Regenerative Matrix? So that you know that when you get a Regenerative Matrix procedure, you’re getting the latest and greatest technology available, not yesterday’s news.