PRP - Platelet Lysate

You may have heard of platelet rich plasma or PRP, which is concentrating blood platelets and injecting them to prompt healing. Platelet Lysate (PL) is it’s more advanced cousin. We first began using PL in orthopedic injuries in 2005. It’s just now starting to catch on via other clinics trying to replicate what we do.

what is platelet lysate and why is it important?

Platelets live in your blood. They are little fragments of cells that are stocked with growth factors and initiate clotting. When you get a cut, it bleeds and the platelets are nanomachines that help to stop the bleeding via a blood clot. The clot is more than just glue to stop the flow of blood out of damaged vessels, it’s also nature’s advanced biologic scaffold to initiate and support healing. Within that healing matrix are billions of platelets that excrete growth factors. These specialized chemicals “speak” to other cells, telling them what to do and energizing the construction effort. We like to tell patients that these growth factors inside platelets act like espresso shots for the cells that are repairing damaged tissue.

PRP is simply concentrating the platelets in the blood. PRP works by concentrated platelets slowly releasing growth factors over approximately a week. Sort of like a timed release version of a pill. What if you want an immediate release version with many more growth factors available all at once? You use a platelet lysate (PL). In our experience while PRP can cause inflammation, PL is very anti-inflammatory and hence can be used more easily around nerves. The 1st generation PRPs were red and the newer PRPs are amber, having eliminated the pro-inflammatory red and white blood cells. Our 2nd generation PRP can be concentrated to ultra-high levels, so we call it SCP (Super Concentrated Platelets). At this time we are the only clinic in Brevard County using this 2nd generation PRP.

What does platelet lysate help with?

Ultimately, PL help multiple injuries and diseases in such areas as shoulder, neck, spine, knees, ankles and feet, hips, wrists and hands, elbows, hair restoration, and skin impurities. Example: Epidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficiency is limited. In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet rich plasma (PRP) instead of epidural injections for the treatment of radicular pain as an alternative to corticosteroids.

conclusion

The upshot? While the rest of the world is struggling to figure out how to make a first generation platelet lysate, we’ve been using our third generation procedure for over a year and are now working on the fourth generation procedure. Why spend all of the money on continually improving what we do at Regenerative Matrix? So that you know that when you get a Regenerative Matrix procedure, you’re getting the latest and greatest technology available, not yesterday’s news.


Stem Cells

Stem cells are the foundation for every organ and tissue in your body. There are many different types of stem cells that come from different places in the body or are formed at different times in our lives. These include MSC cells that exist only at the earliest stages of development and various types of tissue-specific (or adult) stem cells that appear during fetal development and remain in our bodies throughout life.

All stem cells can self-renew (make copies of themselves) and differentiate (develop into more specialized cells). Beyond these two critical abilities, though, stem cells vary widely in what they can and cannot do and in the circumstances under which they can and cannot do. Our goal at Regenerative Matrix is to ensure that all of our clients find relief from painful Arthritic Conditions and can regenerate with Stem Cells.

STEM CELLS and how they work

You may hear the term “mesenchymal stem cell” or MSC to refer to cells isolated from stroma, the connective tissue that surrounds other tissues and organs. Cells by this name are more accurately called “stromal cells” by many scientists. The first MSCs were discovered in the bone marrow and were shown to be capable of making bone, cartilage and fat cells. Since then, they have been grown from other tissues, such as fat and cord blood. Various MSCs are thought to have stem cell, and even immunomodulatory, properties and are being tested as treatments for a great many disorders. Mesenchymal stem cells (MSCs) are an example of tissue or 'adult' stem cells. They are ‘multipotent’, meaning they can produce more than one type of specialized cell of the body, but not all types. MSCs make the different specialized cells found in the skeletal tissues. For example, they can differentiate − or specialize − into cartilage cells (chondrocytes), bone cells (osteoblasts) and fat cells (adipocytes). These specialized cells each have their own characteristic shapes, structures and functions, and each belongs in a particular tissue.

Some early research suggested that MSCs might also differentiate into many different types of cells that do not belong to the skeletal tissues, such as nerve cells, heart muscle cells, liver cells and endothelial cells, which form the inner layer of blood vessels.

Delivery Methods can include the following :

IntraVenous - in which the stem cells are administered directly into the vein.

Directly into the Site - in which stems cells are injected to the area in need of repair.


How could stem cells help in Rheumatoid Arthritis Stem Cell Therapy and OsteoArthritis ?

Immune suppressive agents such as steroids, methotrexate, cyclosporine, gold and infliximab are typically prescribed to treat autoimmune conditions, such as RA, however with the possibility of long term adverse effects. Also, these medications do little to address the damage already done to the joints and extra-articular tissues.

conclusion

At Regenerative Matrix, we evaluate our clients to give them the greater advantages of all approaches, PRP and Stem Cells. Additionally we try to determine stem cells’ role in improving Rheumatoid Arthritis complications and Osteo Arthritis, specifically inflammation and tissue damage.